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6-hydroxynicotinate reductase

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6-hydroxynicotinate reductase
Identifiers
EC no.1.3.7.1
CAS no.9030-84-6
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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In enzymology, a 6-hydroxynicotinate reductase (EC 1.3.7.1) is an enzyme that catalyzes the chemical reaction

6-oxo-1,4,5,6-tetrahydronicotinate + oxidized ferredoxin 6-hydroxynicotinate + reduced ferredoxin

Thus, the two substrates of this enzyme are 6-oxo-1,4,5,6-tetrahydronicotinate and oxidized ferredoxin, whereas its two products are 6-hydroxynicotinate and reduced ferredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is 6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase. Other names in common use include 6-oxotetrahydronicotinate dehydrogenase, 6-hydroxynicotinic reductase, HNA reductase, and 1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase.

References

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  • Holcenberg JS, Tsai L (1969). "Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid". J. Biol. Chem. 244 (5): 1204–11. PMID 5767303.